The Addison disease is the only disease that makes your skin look tan.

Addison’s disease also called adrenal insufficiency, or hypocortisolism occurs when the adrenal glands do not produce enough of the hormone cortisol and, in some cases, the hormone aldosterone. The disease occurs in all age groups and afflicts men and women equally.

Addison’s disease occurs when the adrenal glands do not produce enough of the hormone cortisol and, in some cases, the hormone aldosterone. The disease is also called adrenal insufficiency, or hypocortisolism. Failure to produce adequate levels of cortisol can occur for different reasons. The problem may be due to a disorder of the adrenal glands themselves (primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).

The disease is characterized by weight loss, muscle weakness, fatigue, low blood pressure, and sometimes darkening of the skin in both exposed and nonexposed parts of the body. Other symptoms are sudden penetrating pain in the lower back, abdomen, or legs, severe vomiting and diarrhea, dehydration, low blood pressure, and loss of consciousness. The symptoms begin gradually and may eventually become chronic.

Treatment of Addison’s disease involves replacing, or substituting, the hormones the adrenal glands are not making. Cortisol is replaced orally with hydrocortisone tablets, and aldosterone is replaced with oral doses of a mineralocorticoid called fludrocortisone acetate

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